THE PDAC EXTRACELLULAR MATRIX: A REVIEW OF THE ECM PROTEIN COMPOSITION, TUMOR CELL INTERACTION, AND THERAPEUTIC STRATEGIES

The PDAC Extracellular Matrix: A Review of the ECM Protein Composition, Tumor Cell Interaction, and Therapeutic Strategies

Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is interlaced with a collagen-based extracellular matrix (ECM) that plays an important click here role in tumor biology.Traditionally thought to only provide a physical barrier from host responses and systemic chemotherapy, new studies have demonstrated that the E

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